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Osteoarthritis Treatment
Virus-inspired lipopeptide-derived nucleic acid delivery to cartilage for osteoarthritis therapy
Published:10/16/2025
Virus-Inspired Lipopeptide NanoparticlesOptimized Gene Delivery VectorsCartilage-Targeted Gene TherapyROS-Responsive Nano-in-Gel SystemOsteoarthritis Treatment
This study developed virusinspired lipopeptide nanoparticles (VPN) for RNA delivery in osteoarthritis therapy. The optimized VPN2 showed a 2.5fold increase in transfection efficiency and effectively alleviated cartilage degeneration in mice, highlighting its potential for cart
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The potential of undenatured type II collagen against arthritis: a review
Published:5/1/2024
Undenatured Type II CollagenOsteoarthritis TreatmentRheumatoid Arthritis TreatmentOral Tolerance MechanismBone and Joint Disease Therapy
This review highlights undenatured type II collagen's potential in arthritis treatment, showing oral intake induces tolerance that reduces joint inflammation in osteoarthritis and rheumatoid arthritis, with promising clinical application prospects.
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